Boisier P, Ranaivoson G, Rasolofonirina N, Andriamahefazafy
B, Roux J, Chanteau S, Satake M, Yasumoto T. [Fatal
ichthyosarcotoxism after eating shark meat. Implications of
two new marine toxins] Arch Inst Pasteur Madagascar.
A fish poisoning involving 188 hospitalizations occurred in
November 1993, in Manakara, a middle-sized town on the
south-east coast of Madagascar, following the ingestion of
shark. A single shark was involved in this poisoning and
identified as Carcharinus leucas. There was no unusual
of this shark or its meat. The attack rate was about
100%. First clinical signs appeared within five to ten
after ingestion. The patients presented neurological
almost exclusively, the most prominent being a constant,
ataxia. Gastrointestinal troubles, like diarrhoea and
were rare. The overall case-fatality ratio was close to 30%
among the 200 poisoned inhabitants. Search for similar poi-soning
previously reported in this area was negative, and fish-ermen
in Manakara usually eat that kind of shark without mis-trust.
Bacteriological and chemical origins were eliminated.
Two liposoluble toxins were isolated from the shark liver
tentatively named carchatoxin-A and -B respectively. They
were distinct from ciguatoxin in chromatographic properties