Neuroprotección
en isquemia cerebral aguda. Estado actual e importancia clínica de la
cascada isquémica
NOTE: Translated
using software of
translation of
Spanish to English
Abstract:
Knowledge of
physiophatological
mechanisms of
cerebral ischemia
permits
understanding the
mechanisms of action
on which many
aspects of treatment
are based and the
clinical and neuro-radiological
changes. The only
treatment with
clinically
demonstrated success
is the use of
thrombolytic to
restore the cerebral
circulation. A
cellular and
molecular mechanisms
such as free radical
production, lipid
peroxidation,
excitotoxicity and
calcium ion overload
constitute the
important
therapeutic targets
of neuroprotection
and it is now known
that interventions
such a delivering
neuroprotective
agents can
participate to
salvage a
portentially
reversible ischaemic
region known as the
ischaemic penumbra.
We review the
vascular and
biochemistry that
produce necrosis of
neurons after a
cerebrovascular
occlusion and actual
evidence of
neuroprotective
drugs.
Author:
Ecuadorian
magazine of neurology
