Mùltiple
sclerosis, Virus of
the Herpes Human 6
Type and
Chlamydophila
Pneumoniae
NOTE: Translated
using software of
translation of
Spanish to English
ABSTRACT:
Background and objectives:
An increasing number of papers are showing a relationship between two
infectious agents, human herpes virus 6 (HHV6) and Chlamydophila
pneumoniae (Cp), and multiple sclerosis (MS), although these
results remain controversial. The objectives was a meta-analysis of
clinical series published in literature until now. Material and
Methods: An electronic database search (Medline, Excerpta Medica and
IME) was performed with MS relapsing remitting and the infectious agents
as keywords. A strict selection criteria was applied. 16 studies were
selected who complained with the methodological criteria. Results:
After statistical analysis, we found that HHV6 was related with MS by
detection of DNA in plasma and antibodies in serum and cerebrospinal
fluid, but not with DNA in cerebrospinal fluid or peripheral blood white
cells. Cp was related with MS by detection of DNA in cerebrospinal
fluid, antibodies and the isolation of bacteria of cerebrospinal fluid,
but not with serum antibodies. Conclusions: A study with enough
number of patients and samples, prospective, controlled with healthy
subjects and other neurological diseases, with multiple microbiological
techniques in the same sample and patient, and correlated with clinical
and paraclinical activity parameters, are needed.
Author:
Ecuadorian
magazine of neurology
